Paroxysmal dyskinesia in cats… it can be associated with hyperthyroidism!

Journal Article

Paroxysmal dyskinesia associated with hyperthyroidism in 7 cats: a novel manifestation of a metabolic encephalopathy Open Access

Javier Espinosa ,

Irene Espadas ,

Athina Karpozilou ,

Tamara Heredia ,

Alenka Hrovat ,

Juan Torre ,

Annette Wessmann ,

Aga Zoltowska ,

Charlotte Dye ,

Juan José Mínguez

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Journal of Veterinary Internal Medicine, Volume 40, Issue 1, January-February 2026, aalaf007, https://doi.org/10.1093/jvimsj/aalaf007

Published:

21 January 2026

Article history

Abstract

Background

Paroxysmal dyskinesia associated with hyperthyroidism (HT) is a well-described disorder in humans and has not been previously reported in cats.

Hypothesis/Objectives

Paroxysmal dyskinesia might develop as a consequence of HT in cats, with improvement or cessation of the episodes once normal thyroid function is restored.

Animals

Seven client-owned cats.

Methods

Multicenter retrospective observational study comprising cats with clinical signs consistent with the clinical phenotype of paroxysmal dyskinesia based on video recordings, and a concurrent diagnosis of HT. Follow-up information was obtained by contacting referring veterinarians and owners.

Results

Seven cats were included. No signs of neurological disease were observed between the episodes except for plantigradism in one cat. Brain MRI studies were performed in 2 cats, revealing no intracranial abnormalities. In 1 cat, a 2-h video-assisted wireless electroencephalography confirmed the absence of epileptic activity. Clinical signs associated with HT were noted in all but 1 cat. After treatment for HT, complete remission of paroxysmal dyskinesia episodes was achieved in all cases, with euthyroid state confirmed in 6 cats.

Conclusions and clinical importance

HT should be considered a differential diagnosis in cats with paroxysmal dyskinesia, even in the absence of other suggestive signs. Similar to the analogous disorder in humans, the prognosis appears excellent once appropriate treatment for HT is initiated.

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